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USMLE · Question #290

A drug ending in the suffix (azole) is considered a ______.

The correct answer is C. Antifungal. Drugs ending in -azole are antifungals - examples include fluconazole, itraconazole, and ketoconazole, all of which work by inhibiting ergosterol synthesis in fungal cell membranes. Why the distractors are wrong: A (H₂ blocker): H₂ blockers (histamine-2 receptor antagonists)…

Principles of Therapeutics

Question

A drug ending in the suffix (azole) is considered a ______.

Options

  • AH
  • BACE inhibitor
  • CAntifungal
  • DBeta agonist

How the community answered

(50 responses)
  • A
    18% (9)
  • B
    6% (3)
  • C
    72% (36)
  • D
    4% (2)

Explanation

Drugs ending in -azole are antifungals - examples include fluconazole, itraconazole, and ketoconazole, all of which work by inhibiting ergosterol synthesis in fungal cell membranes.

Why the distractors are wrong:

  • A (H₂ blocker): H₂ blockers (histamine-2 receptor antagonists) use suffixes like -tidine (e.g., ranitidine, famotidine).
  • B (ACE inhibitor): ACE inhibitors end in -pril (e.g., lisinopril, enalapril).
  • D (Beta agonist): Beta agonists typically end in -ol for beta blockers or -terol/-buterol for agonists (e.g., albuterol, salmeterol).

Memory tip: Think of "azole = a-zap-the-fungus" - the "-azole" suffix is almost exclusively associated with antifungals. When you see it on an exam, antifungal should be your immediate reflex.

Topics

#antifungal drugs#drug nomenclature#azole class#pharmacology

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