USMLE · Question #290
A drug ending in the suffix (azole) is considered a ______.
The correct answer is C. Antifungal. Drugs ending in -azole are antifungals - examples include fluconazole, itraconazole, and ketoconazole, all of which work by inhibiting ergosterol synthesis in fungal cell membranes. Why the distractors are wrong: A (H₂ blocker): H₂ blockers (histamine-2 receptor antagonists)…
Question
A drug ending in the suffix (azole) is considered a ______.
Options
- AH
- BACE inhibitor
- CAntifungal
- DBeta agonist
How the community answered
(50 responses)- A18% (9)
- B6% (3)
- C72% (36)
- D4% (2)
Explanation
Drugs ending in -azole are antifungals - examples include fluconazole, itraconazole, and ketoconazole, all of which work by inhibiting ergosterol synthesis in fungal cell membranes.
Why the distractors are wrong:
- A (H₂ blocker): H₂ blockers (histamine-2 receptor antagonists) use suffixes like -tidine (e.g., ranitidine, famotidine).
- B (ACE inhibitor): ACE inhibitors end in -pril (e.g., lisinopril, enalapril).
- D (Beta agonist): Beta agonists typically end in -ol for beta blockers or -terol/-buterol for agonists (e.g., albuterol, salmeterol).
Memory tip: Think of "azole = a-zap-the-fungus" - the "-azole" suffix is almost exclusively associated with antifungals. When you see it on an exam, antifungal should be your immediate reflex.
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