USMLE · Question #599
A 24-year-old female comes to the physician due to urinary frequency and burning with urination. She is diagnosed with a urinary tract infection and prescribed ciprofloxacin. The exposure of a fetus…
The correct answer is A. cartilage damage. Fluoroquinolones are a class of antibiotics which work by inhibiting topoisomerase II and IV in prokaryotes. These drugs include ciprofloxacin, ofloxacin, gemifloxacin and enoxacin. They should not be taken together with antacids. They are used in the treatment of urinary and…
Question
A 24-year-old female comes to the physician due to urinary frequency and burning with urination. She is diagnosed with a urinary tract infection and prescribed ciprofloxacin. The exposure of a fetus to ciprofloxacin can result in:
Options
- Acartilage damage
- Bdiscolored teeth
- Cgray baby syndrome
- Dkernicterus
- Eototoxicity
How the community answered
(26 responses)- A81% (21)
- B12% (3)
- D4% (1)
- E4% (1)
Explanation
Fluoroquinolones are a class of antibiotics which work by inhibiting topoisomerase II and IV in prokaryotes. These drugs include ciprofloxacin, ofloxacin, gemifloxacin and enoxacin. They should not be taken together with antacids. They are used in the treatment of urinary and GI tract infections with gram-negative bacteria. They are contraindicated in pregnant women, nursing mothers and children < 18 years old due to possible cartilage damage. Other side effects of fluoroquinolones include QT interval prolongation, tendon rupture in patients over 60 years old, skin rashes, dizziness and inhibition of cytochrome P-450 enzymes.
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