Which of the following drugs is associated with the reaction of hepatitis?

The correct answer is C. Isoniazid. Isoniazid (INH), a first-line antituberculosis drug, is the classic cause of drug-induced hepatitis - approximately 10–20% of patients develop elevated transaminases, and ~1% progress to clinical hepatitis, caused by a toxic metabolite (acetylhydrazine) produced during…

Principles of Therapeutics

Question

Options

AValproic acid
BQuinidine
CIsoniazid
DEthosuximide

How the community answered

(27 responses)

A
7% (2)
B
4% (1)
C
78% (21)
D
11% (3)

Explanation

Isoniazid (INH), a first-line antituberculosis drug, is the classic cause of drug-induced hepatitis - approximately 10–20% of patients develop elevated transaminases, and ~1% progress to clinical hepatitis, caused by a toxic metabolite (acetylhydrazine) produced during acetylation. Valproic acid can cause hepatotoxicity (especially in children), but its hallmark adverse effects are hyperammonemia, pancreatitis, and teratogenicity - not hepatitis specifically. Quinidine is associated with cinchonism (tinnitus, headache), thrombocytopenia, lupus-like syndrome, and torsades de pointes - not hepatitis. Ethosuximide's notable adverse effects include Stevens-Johnson syndrome, aplastic anemia, and lupus-like reactions, not hepatitis.

Memory tip: Think "INH = I iNjure Hepatocytes" - isoniazid is the prototypical drug-induced hepatitis agent, and monitoring LFTs is mandatory during TB therapy.

Topics

#Drug-induced hepatitis#Isoniazid toxicity#Tuberculosis medications#Adverse drug effects

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