A 65-year-old male who had a cholecystectomy at a local hospital experiences nausea and vomiting two days later. He is prescribed metoclopramide by the resident physician. Metoclopramide is…

The correct answer is D. Parkinson disease. This patient most likely has post-surgery gastroparesis. Metoclopramide is a D_2 receptor antagonist which increases intestinal motility, contractility and lower esophageal sphincter tone. It also promotes gastric emptying. Metoclopramide is commonly used to treat diabetic and…

Principles of Therapeutics

Question

A 65-year-old male who had a cholecystectomy at a local hospital experiences nausea and vomiting two days later. He is prescribed metoclopramide by the resident physician. Metoclopramide is contraindicated in patients with:

Options

Acoronary artery disease
Bliver cirrhosis
Cmigraine headaches
DParkinson disease
Eurinary tract infections

How the community answered

(44 responses)

A
11% (5)
B
5% (2)
C
2% (1)
D
80% (35)
E
2% (1)

Explanation

This patient most likely has post-surgery gastroparesis. Metoclopramide is a D_2 receptor antagonist which increases intestinal motility, contractility and lower esophageal sphincter tone. It also promotes gastric emptying. Metoclopramide is commonly used to treat diabetic and post- surgical gastroparesis, gastroesophageal reflux disease and chemotherapy induced nausea and vomiting. Its side effects include parkinsonism, tardive dyskinesia, diarrhea, depression and restlessness. It is contraindicated in patients with Parkinson disease and small bowel obstruction.

Topics

#metoclopramide#Parkinson disease#dopamine antagonist#drug contraindications

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