USMLE · Question #289
A drug ending in the suffix (pril) is considered a ______.
The correct answer is B. ACE inhibitor. Drugs ending in -pril are ACE (Angiotensin-Converting Enzyme) inhibitors, a class of medications used to treat hypertension and heart failure by blocking the enzyme that converts angiotensin I to angiotensin II, reducing blood vessel constriction. Common examples include…
Question
A drug ending in the suffix (pril) is considered a ______.
Options
- AH
- BACE inhibitor
- CA ntifungal
- DBeta agonist
How the community answered
(33 responses)- A3% (1)
- B82% (27)
- C6% (2)
- D9% (3)
Explanation
Drugs ending in -pril are ACE (Angiotensin-Converting Enzyme) inhibitors, a class of medications used to treat hypertension and heart failure by blocking the enzyme that converts angiotensin I to angiotensin II, reducing blood vessel constriction. Common examples include lisinopril, enalapril, and captopril - all sharing the -pril suffix as a naming convention for this drug class.
Why the distractors are wrong:
- A (H) - is not a drug class at all; it's an incomplete option likely referencing antihistamines (-ine suffix) or H2 blockers (-tidine suffix), neither of which matches -pril.
- C (Antifungal) - antifungals typically end in suffixes like -azole (fluconazole) or -fungin (caspofungin), not -pril.
- D (Beta agonist) - beta agonists (bronchodilators) follow suffixes like -terol (albuterol, salmeterol), not -pril.
Memory tip: Think "pril = pressure pill" - ACE inhibitors lower blood pressure, and the -pril ending is your clue. You can also anchor it to the prototype drug captopril, the first ACE inhibitor ever approved.
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