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USMLE · Question #289

A drug ending in the suffix (pril) is considered a ______.

The correct answer is B. ACE inhibitor. Drugs ending in -pril are ACE (Angiotensin-Converting Enzyme) inhibitors, a class of medications used to treat hypertension and heart failure by blocking the enzyme that converts angiotensin I to angiotensin II, reducing blood vessel constriction. Common examples include…

Principles of Therapeutics

Question

A drug ending in the suffix (pril) is considered a ______.

Options

  • AH
  • BACE inhibitor
  • CA ntifungal
  • DBeta agonist

How the community answered

(33 responses)
  • A
    3% (1)
  • B
    82% (27)
  • C
    6% (2)
  • D
    9% (3)

Explanation

Drugs ending in -pril are ACE (Angiotensin-Converting Enzyme) inhibitors, a class of medications used to treat hypertension and heart failure by blocking the enzyme that converts angiotensin I to angiotensin II, reducing blood vessel constriction. Common examples include lisinopril, enalapril, and captopril - all sharing the -pril suffix as a naming convention for this drug class.

Why the distractors are wrong:

  • A (H) - is not a drug class at all; it's an incomplete option likely referencing antihistamines (-ine suffix) or H2 blockers (-tidine suffix), neither of which matches -pril.
  • C (Antifungal) - antifungals typically end in suffixes like -azole (fluconazole) or -fungin (caspofungin), not -pril.
  • D (Beta agonist) - beta agonists (bronchodilators) follow suffixes like -terol (albuterol, salmeterol), not -pril.

Memory tip: Think "pril = pressure pill" - ACE inhibitors lower blood pressure, and the -pril ending is your clue. You can also anchor it to the prototype drug captopril, the first ACE inhibitor ever approved.

Topics

#drug nomenclature#ACE inhibitors#pharmacology

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