A 24-year-old female comes to the physician due to urinary frequency and burning with urination. She is diagnosed with a urinary tract infection and prescribed ciprofloxacin. The mechanism of action…

The correct answer is D. inhibition of DNA gyrase. Fluoroquinolones are a class of antibiotics which work by inhibiting topoisomerase II also called DNA gyrase and IV in prokaryotes. These drugs include ciprofloxacin, ofloxacin, gemifloxacin and enoxacin. They should not be taken together with antacids. They are used in the…

Principles of Therapeutics

Question

A 24-year-old female comes to the physician due to urinary frequency and burning with urination. She is diagnosed with a urinary tract infection and prescribed ciprofloxacin. The mechanism of action of ciprofloxacin is by

Options

Acreation of transmembrane channels
Binhibition of cell wall synthesis
Cinhibition of dihydrofolate reductase
Dinhibition of DNA gyrase
Einhibition of protein synthesis

How the community answered

(59 responses)

A
3% (2)
B
2% (1)
C
5% (3)
D
80% (47)
E
10% (6)

Explanation

Fluoroquinolones are a class of antibiotics which work by inhibiting topoisomerase II also called DNA gyrase and IV in prokaryotes. These drugs include ciprofloxacin, ofloxacin, gemifloxacin and enoxacin. They should not be taken together with antacids. They are used in the treatment of urinary and GI tract infections with gram-negative bacteria. They are contraindicated in pregnant women, nursing mothers and children < 18 years old due to possible cartilage damage. Other side effects of fluoroquinolones include QT interval prolongation, tendon rupture in patients over 60 years old, skin rashes, dizziness and inhibition of cytochrome P-450 enzymes.

Topics

#ciprofloxacin#fluoroquinolones#DNA gyrase inhibition#antibiotic mechanism

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