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USMLE · Question #487

A couple comes for preconceptional genetic counseling because they both have a family history of -thalassemia. The woman has a minimally decreased hemoglobin concentration. Genetic studies show a sing

The correct answer is C. 50%. See the full explanation below for the reasoning.

Question

A couple comes for preconceptional genetic counseling because they both have a family history of -thalassemia. The woman has a minimally decreased hemoglobin concentration. Genetic studies show a single gene deletion. The man has microcytic anemia and a two-gene deletion. If the two-gene deletion is in trans (one deletion on the maternal gene and one deletion on the paternal gene), which of the following percentages of their offspring will have a two-gene deletion?

Options

  • A0%
  • B25%
  • C50%
  • D75%
  • E100%

How the community answered

(50 responses)
  • A
    2% (1)
  • B
    14% (7)
  • C
    74% (37)
  • D
    6% (3)
  • E
    4% (2)

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