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USMLE · Question #541

Six healthy subjects participate in a study of muscle metabolism during which hyperglycemia and hyperinsulinemia is induced. Muscle biopsy specimens obtained from the subjects during the resting…

The correct answer is A. Fatty acid oxidation. See the full explanation below for the reasoning.

Question

Six healthy subjects participate in a study of muscle metabolism during which hyperglycemia and hyperinsulinemia is induced. Muscle biopsy specimens obtained from the subjects during the resting state show significantly increased concentrations of malonyl-CoA. The increased malonyl- CoA concentration most likely directly inhibits which of the following processes in these subjects?

Options

  • AFatty acid oxidation
  • BFatty acid synthesis
  • CGluconeogenesis
  • DGlycogenolysis
  • EGlycolysis
  • FOxidative phosphorylation

How the community answered

(40 responses)
  • A
    73% (29)
  • B
    3% (1)
  • C
    5% (2)
  • E
    15% (6)
  • F
    5% (2)

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