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USMLE · Question #505
USMLE Question #505: Real Exam Question with Answer & Explanation
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Question
A 54-year-old woman comes to the emergency department because of severe jaw pain since undergoing a painful dental procedure 1 day ago. The patient was prescribed codeine after the procedure and instructed to take the medication every 4 hours, but she has continued pain despite adherence to this analgesic regimen. Other members of her family also have experienced poor pain control with codeine. Which of the following is the most likely explanation for this therapeutic failure?
Options
- ADecreased absorption of codeine
- BDecreased metabolism of codeine to morphine
- CDeficiency of κ receptors
- DIncreased plasma protein-binding of codeine
- EIncreased renal clearance of codeine
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