USMLE · Question #484
A 33-year-old woman comes to the physician because of a 2-day history of mild nausea, increased urinary urgency and frequency, and constipation. She also has had a 4.5-kg (10-lb) weight loss during th
The correct answer is A. Inactivation of celluar p53. See the full explanation below for the reasoning.
Question
A 33-year-old woman comes to the physician because of a 2-day history of mild nausea, increased urinary urgency and frequency, and constipation. She also has had a 4.5-kg (10-lb) weight loss during the past 2 weeks and a 3-week history of vaginal bleeding. Pelvic examination shows a nodular cervix with an irregular, friable posterior lip, and a rock-hard, irregular, immobile pelvic mass that extends across the pelvis. Examination of biopsy specimens from the cervix and anterior wall of the vagina show well-differentiated keratinizing squamous cell carcinoma. Which of the following best describes the pathogenesis of this patient's disease?
Options
- AInactivation of celluar p53
- BInsertion of viral promotors adjacent to cellular growth factor genes
- CSpecialized transduction
- DTransactivation of cellular growth factor genes by TAX
- ETranslocation of CMYC to an Ig gene promoter
How the community answered
(33 responses)- A82% (27)
- B9% (3)
- C3% (1)
- E6% (2)
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