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USMLE · Question #484

A 33-year-old woman comes to the physician because of a 2-day history of mild nausea, increased urinary urgency and frequency, and constipation. She also has had a 4.5-kg (10-lb) weight loss during th

The correct answer is A. Inactivation of celluar p53. See the full explanation below for the reasoning.

Question

A 33-year-old woman comes to the physician because of a 2-day history of mild nausea, increased urinary urgency and frequency, and constipation. She also has had a 4.5-kg (10-lb) weight loss during the past 2 weeks and a 3-week history of vaginal bleeding. Pelvic examination shows a nodular cervix with an irregular, friable posterior lip, and a rock-hard, irregular, immobile pelvic mass that extends across the pelvis. Examination of biopsy specimens from the cervix and anterior wall of the vagina show well-differentiated keratinizing squamous cell carcinoma. Which of the following best describes the pathogenesis of this patient's disease?

Options

  • AInactivation of celluar p53
  • BInsertion of viral promotors adjacent to cellular growth factor genes
  • CSpecialized transduction
  • DTransactivation of cellular growth factor genes by TAX
  • ETranslocation of CMYC to an Ig gene promoter

How the community answered

(33 responses)
  • A
    82% (27)
  • B
    9% (3)
  • C
    3% (1)
  • E
    6% (2)

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