USMLE · Question #476
A 45-year-old woman with systemic sclerosis (scleroderma) comes to the physician because of a 3-week history of progressive shortness of breath and nonproductive cough. Her temperature is 36.9°C…
The correct answer is A. Diffuse interstitial fibrosis. See the full explanation below for the reasoning.
Question
A 45-year-old woman with systemic sclerosis (scleroderma) comes to the physician because of a 3-week history of progressive shortness of breath and nonproductive cough. Her temperature is 36.9°C (98.4°F), pulse is 82/min, respirations are 20/min, and blood pressure is 136/85 mmHg. Crackles are heard in both lower lung fields. Pulmonary function tests show total lung capacity is 80% of predicted, and diffusing capacity for carbon monoxide, corrected for alveolar volume, is 65% of predicted. Histologic examination of a lung biopsy specimen is most likely to show which of the following findings?
Options
- ADiffuse interstitial fibrosis
- BIntra-alveolar exudates
- CMultiple thromboemboli
- DNecrotizing vasculitis
- ENon-necrotizing interstitial granulomas
How the community answered
(57 responses)- A72% (41)
- B14% (8)
- C7% (4)
- D2% (1)
- E5% (3)
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