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USMLE · Question #402

A genotypic male (XY) is born with feminized external genitalia. The testes are retained within the abdominal cavity, and the internal reproductive tracts exhibit the normal male phenotype. Which of t

The correct answer is B. 5a-reductase deficiency. See the full explanation below for the reasoning.

Question

A genotypic male (XY) is born with feminized external genitalia. The testes are retained within the abdominal cavity, and the internal reproductive tracts exhibit the normal male phenotype. Which of the following could account for this abnormal development?

Options

  • AComplete androgen resistance
  • B5a-reductase deficiency
  • C17a-hydroxylase deficiency
  • DSertoli-only syndrome
  • ETesticular dysgenesis

How the community answered

(58 responses)
  • A
    2% (1)
  • B
    74% (43)
  • C
    3% (2)
  • D
    9% (5)
  • E
    12% (7)

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