Which Cisco ISE deployment model is recommended for an enterprise that has over 50,000 concurrent active endpoints?

"Large deployment with fully distributed nodes running all personas" is vague and does not align with standard ISE sizing guidance, as running all personas on every node is often not optimal for large-scale deployments.

"Medium deployment with primary and secondary PAN/MnT/pxGrid nodes with shared PSNs" would imply PSN functions are collocated with PAN/MnT, which is not ideal for 50,000+ endpoints due to performance and scalability limitations.

For over 50,000 concurrent active endpoints, a medium deployment is typically recommended. This model involves dedicated primary and secondary nodes for PAN, MnT, and pxGrid (for high availability of administrative, monitoring, and context sharing services), combined with multiple dedicated PSNs to handle the substantial authentication, authorization, and accounting load. Dedicated PSNs ensure scalability and performance for such a large endpoint count.

A "small deployment with one primary and one secondary node running all personas" is suitable for up to 10,000 endpoints and would not scale to over 50,000 concurrent active endpoints due to resource contention and capacity limits.