010-111 · Question #211
Decreased muscle masses as a result of the aging process plays a role in ______ and ______.
The correct answer is A. glucose intolerance, declining independence. Sarcopenia reduces skeletal muscle mass, which impairs insulin-mediated glucose uptake causing glucose intolerance, and diminishes the functional strength needed for daily activities, leading to declining independence.
Question
Decreased muscle masses as a result of the aging process plays a role in ______ and ______.
Options
- Aglucose intolerance, declining independence
- Bglucose tolerance, balance impairment
- Creduced bone mineral density, improved mobility
- Dreduced adiposity, improved independence
How the community answered
(47 responses)- A72% (34)
- B15% (7)
- C4% (2)
- D9% (4)
Why each option
Sarcopenia reduces skeletal muscle mass, which impairs insulin-mediated glucose uptake causing glucose intolerance, and diminishes the functional strength needed for daily activities, leading to declining independence.
Skeletal muscle is the primary site of postprandial, insulin-mediated glucose disposal; a significant reduction in muscle mass decreases this capacity, contributing directly to glucose intolerance and increased type 2 diabetes risk. Concurrently, the loss of muscle mass reduces the force-generating capacity required for ambulation, transfers, and other activities of daily living, causing progressive functional decline and loss of independence.
Decreased muscle mass causes glucose intolerance rather than improved glucose tolerance, making the first term factually incorrect.
While sarcopenia can indirectly affect bone density, 'improved mobility' is incorrect - loss of muscle mass worsens mobility and functional capacity.
Sarcopenia is frequently associated with increased relative adiposity (sarcopenic obesity), not reduced adiposity, and it impairs rather than supports independence.
Concept tested: Sarcopenia effects on glucose metabolism and functional independence
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890914/
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