USMLE · Question #435
A patient presents to a physician with jaundice. Physical examination reveals a nodular, enlarged liver. CT of the abdomen shows a cirrhotic liver with a large mass. CT-guided biopsy of the mass demon
The correct answer is B. Hepatitis B virus (HBV). The tumor is hepatocellular carcinoma, which usually develops in the setting of cirrhosis owing to a variety of damaging agents, including hepatitis B virus (HBV) infection, alcohol use, and hemachromatosis. Epstein-Barr virus (EBV) is associated with Burkitt lymphoma and nasopha
Question
A patient presents to a physician with jaundice. Physical examination reveals a nodular, enlarged liver. CT of the abdomen shows a cirrhotic liver with a large mass. CT-guided biopsy of the mass demonstrates a malignant tumor derived from hepatic parenchymal cells. Infection with which of the following viruses would most likely be directly related to the development of this tumor?
Options
- AEpstein-Barr virus (EBV)
- BHepatitis B virus (HBV)
- CHuman herpesvirus type 8 (HHV 8)
- DHuman papillomavirus (HPV)
- EHuman T-lymphocyte virus (HTLV-1)
How the community answered
(25 responses)- A4% (1)
- B72% (18)
- C8% (2)
- D12% (3)
- E4% (1)
Explanation
The tumor is hepatocellular carcinoma, which usually develops in the setting of cirrhosis owing to a variety of damaging agents, including hepatitis B virus (HBV) infection, alcohol use, and hemachromatosis. Epstein-Barr virus (EBV) is associated with Burkitt lymphoma and nasopharyngeal carcinoma. Human herpesvirus type 8 (HHV 8), a member of the herpes family, is associated with Kaposi sarcoma. Human papillomavirus (HPV) is associated with cervical, penile, and anal carcinoma. Human T-lymphocyte virus (HTLV-1) is associated with adult T-cell
Topics
Community Discussion
No community discussion yet for this question.