A patient presents with cervical lymphadenopathy. Biopsy demonstrates a nodular lymphoma with follicle formation. This lesion would most likely be associated with which of the following?

The correct answer is B. bcl-2 activation. Nodular lymphomas of all types are derived from the B-cell line. The translocation t(14, 18), with bcl-2 activation, is associated with these lymphomas. An abl-bcr hybrid (bcr-c-abl;) and t(9, 22) translocation are associated with chronic myeloid leukemia (CML).c-myc activation…

Abnormal Processes

Question

Options

Abcr-c-abl
Bbcl-2 activation
Cc-myc activation
Dt(8, 14)
Et(9, 22)

How the community answered

(31 responses)

A
3% (1)
B
81% (25)
D
6% (2)
E
10% (3)

Explanation

Nodular lymphomas of all types are derived from the B-cell line. The translocation t(14, 18), with bcl-2 activation, is associated with these lymphomas. An abl-bcr hybrid (bcr-c-abl;) and t(9, 22) translocation are associated with chronic myeloid leukemia (CML).c-myc activation and t(8, 14) are associated with Burkitt lymphoma.

Topics

#follicular lymphoma#bcl-2 activation#t(14;18) translocation#lymphoma genetics

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