Based on your knowledge of genetic inheritance, which of these statements is true for autosomal recessive genetic disorders?

Question

Options

• AHeterozygotes are affected.
• BThe disorder is always carried on the X chromosome.
• COnly females are affected.
• DTwo affected parents always have affected children.

• A
  4% (1)
• C
  8% (2)
• D
  88% (22)

Explanation

(A) The term heterozygote refers to an individual with one normal and one mutant allele at a given locus on a pair of homologous chromosomes. An individual who is heterozygous for the abnormal gene does not manifest obvious symptoms. (B) Disorders carried on either the X or Y sex chromosome are referred to as sex-linked (C) Either sex may be affected by autosomal recessive genetic disorders because the responsible allele can be on any one of the 46 chromosomes. (D) If both parents are affected by the disorder and are not just carriers, then all their children would manifest the same disorder.

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